Migalastat hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Migalastat hydrochloride (GR181413A) 是一种有效和竞争性的 α-galactosidase A 抑制剂，对人 α-Gal A 的 IC50 值为 0.04 μM。

Migalastat hydrochloride (GR181413A) is a potent and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC50 of 0.04 μM for human α-Gal A.

Cell Viability AssayCell Line:EHK cells mutated α-Gal A Concentration:10 μM Incubation Time:9 days Result:Reduced Gb3 accumulation and lysosome volume.

Animal Model:Male nontransgenic (Non-Tg) C57BL/6 mice; transgenic mice expressing human mutant R301Q α-Gal A (TgM), α-Gal A knockout mice (KO), mice express human R301Q α-Gal A in a null background (TgM/KO) Dosage:3 mg/kg Administration: Oral gavage; every day for 4 weeks Result:Reduced Globotriaosylceramide (Gb3) storage remarkably in kidney of mice.

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Other Targets

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75172-81-5

199.63

C6H14ClNO4

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : ≥ 200 mg/mL (1001.85 mM)

Cl.OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years